Wednesday, March 23, 2011

By causing the mutation of one specific gene, researchers have produced mice with two frequently encountered behavioral traits of persons diagnosed with autism. Autism commonly affects the ability to interact socially and is associated with repetitive behavior. The finding was reported in the March 20 online edition of Nature.

Using mice, researchers at the Massachusetts Institute of Technology (MIT) and Duke University mutated one of the genes associated with autism, known as shank3, a gene that controls the production of the shank3 protein present in the brain. Mice that were given this mutation exhibited repetitive behavior and avoided social interactions with the mice around them.

According to MIT Professor Guoping Feng: “Our study demonstrated that Shank3 mutation in mice lead to defects in neuron-neuron communications.”

Shank3 protein are found in synapses within the brain. Synapses allow brain cells (called neurons) to communicate with each other. The mutation in the mouse gene interfered with this communication, apparently producing the subsequent autism-like traits. Researchers believe their work demonstrates the important role of shank3 in the functioning of brain circuits that determine behavior.

While hundreds of genes have been linked to autism in human patients, only a small percentage have been linked to shank3. Professor Feng hypothesizes that disruptions of other genes that act on the production of brain proteins affecting synaptic communication may also be related to autistic behavior. If this disruption is real, Feng claims that treatments could be developed to correct synaptic function for any defective synaptic protein in an autistic patient.

Feng continued; “These findings and the mouse model now allow us to figure out the precise neural circuit defects responsible for these abnormal behaviours, which could lead to novel strategies and targets for developing treatment.”

About one in 110 children in the U.S., and at least one in 100 in UK, have been diagnosed with an autism spectrum disorder, for which there is currently no effective cure.

Thursday, March 31, 2005A report Tuesday from a United Nations-backed project, consulting more than 1,300 scientists from 95 countries, and written over the last four years, warns that 60 percent of the basics of life on Earth — water, food, timber, clean air — are currently being used in ways which degrade them. Furthermore, fisheries and fresh water use-patterns are unsustainable, and getting worse.

“The harmful consequences of this degradation could grow significantly worse in the next 50 years,” according to a press release from the Millennium Ecosystem Assessment (MA), a massive four-year study begun in 2001.

“We’ve had many reports on environmental degradation, but for the first time we’re now able to draw connections between ecosystem services and human well-being,” Cristian Samper, director of the Smithsonian Institution’s National Museum of Natural History in Washington and a chief architect of the study, told the Christian Science Monitor.

The project’s Synthesis Report, first in a series of eleven documents and published yesterday, explains the objective: “to assess the consequences of ecosystem change for human well-being and to establish the scientific basis for actions needed to enhance the conservation and sustainable use of ecosystems and their contributions to human well-being.”

It then goes on to report on four main findings:

• Changes over the last 50 years to meet rapidly growing demands for food, fresh water, timber, fiber and fuel, have effected substantial and largely irreversible loss in the diversity of life on Earth.

• Net gains in human well-being and economic development are offset by growing costs, in the form ecosystem degradation, the possibility of abrupt and unpredictable ecosystem changes, and worsened poverty for some groups. Unless addressed, these problems will substantially diminish the benefits that future generations obtain from ecosystems.

• Ecosystem degradation could grow significantly worse over the next 50 years, presenting a barrier to meeting UN Millennium Development Goals.

• The challenge of reversing the degradation while meeting increasing ecological demands can be partially met under some scenarios, but only with significant changes in policies, institutions and practices — changes that are not currently under way.

Walter Reid, the study’s director, speaking at yesterday’s London launch of the report said it shows that over the last 50 years “humans have changed ecosystems more rapidly and extensively than in any comparable time in human history.”

“This has resulted in substantial and largely irreversible loss in the diversity of life on Earth,” he said.

It is unclear what this will mean to future generations or the possible emergence of new diseases, absence of fresh water and the continuing decline of fisheries and completely unpredictable weather.

With half of the urban populations of Africa, Asia, Latin America and the Caribbean suffering from several diseases associated with these problems, the death toll is reaching 1.7 million people a year. Entire species of mammals, birds and amphibians are disappearing from the planet at nearly 1,000 times the natural rate, according to the study. Oxygen-depleted coastal waters and rivers result from overuse of nitrogen fertilizer – an effect known as “nutrient loading” which leads to continuing biodiversity loss.

With the United States’ non-participation in the Kyoto Treaty, former U.S. Senator Timothy Wirth, president of this U.N. Foundation, says “U.S. leadership is critical in providing much-needed expertise, technological capabilities and ingenuity to restore ecosystems.

“We can take steps at home to reduce our nation’s adverse impact on the global environment.”

“At the heart of this assessment is a stark warning,” said the 45-member board.

Wednesday, March 23, 2011

Friday, a song by US teen singer Rebecca Black, has gone viral after the song’s music video was uploaded onto video sharing website YouTube. The video has attracted over thirty-five million views since its February 10 upload — and critics think it could be the world’s worst.

Ark Music Factory produced the song and video, using US$2,000 (£1,223, C$1,964, €1,412) from Black’s mother. Friday’s video was shot at Black’s father’s house, with her family and friends as extras. The song beat an alternative track when choosing what to record.

The single is climbing up the iTunes singles chart in the United Kingdom and the United States, gaining a higher position in the US than Canadian singer Justin Bieber.

Despite the song’s popularity, it has received a largely negative reception. According to Newsbeat, critics have cited Friday as being “the worst song of all time.” On YouTube, the video attracted approximately thirty-six thousand ‘likes’ versus over 314,000 ‘dislikes’. The song itself has been ridiculed for its lyrics and criticised for its use of Auto-Tune.

Feeling “like [she was] being cyber-bullied,” Rebecca Black said “[w]hen I first saw all these nasty comments I thought this is all my fault, … this was all because of me.” Black says of “[t]hose hurtful comments”, the worst was “I hope you cut yourself and I hope you get an eating disorder so you look pretty. I hope you cut and die.” Clarence Jey, of Ark Music Factory, offered to take the video off YouTube, but Black declined.

In contrast, British music executive Simon Cowell has expressed a positive interest in Rebecca Black. “I love her and the fact she’s gotten so much publicity,” Cowell commented. “People are so upset about the song, but I think it’s hysterical. I want to meet her. Anyone who can create this much controversy within a week, I want to meet. I love people like that.”

Rebecca Black herself wants to record a duet with Justin Bieber. “I have Bieber fever — I am in love with Justin Bieber,” Black commented. The teenager said it “would be unbelievable and make my life”.

Thursday, April 27, 2006

By the decision of the shareholders the “Voxtel” company will be transformed Into “Orange”.

The shareholders of “Voxtel” are: France Telecom – 61%, MMT-BIS – 30%, MobilRom – 4%, IFC – 5%.

“Orange” – is one of the world mobile communication leaders and is a daughter enterprise of the “France Telecom” group. The “Orange” group is present in 17 countries, where it has more than 80 million mobile communication subscribers.

Thursday, November 12, 2009

Researchers have found a crucial genetic difference between humans and chimps that could help explain our language and speech abilities. The difference lies in a gene called FOXP2 which encodes for a protein of the same name. This acts as a transcription factor, controlling the activity of other genes.

The human and chimp versions of the protein differ in only two of their 740 amino acid components, but when researchers at the University of California, Los Angeles, replaced the human gene with the chimp version in neurons grown in the laboratory, they found it affected the expression of at least 116 other genes.

The results are detailed in a paper published on Thursday in the scientific journal Nature.

Author of the study Dr. Daniel Geschwind, of the David Geffen School of Medicine at UCLA, said the gene had a “major role” in differences between chimps and humans. “We showed that the human and chimp versions of FOXP2 not only look different but function differently too.”

Some of the affected genes control the formation of connections in the brain, whilst others relate to facial movements. Several have already been found to be involved in language disorders. Mutations in FOXP2 itself were also known to affect speech and language; the gene was first identified in members of a family suffering from language problems who were found to share a genetic mutation.

Frances Vargha-Khadem at University College London has studied patients with FOXP2 mutations, and agrees with the new research. As well as language problems, some of her subjects have changes in the shape of their jaws, mouths and tongues. She thinks that chimps may also have these differences.

“We believe FOXP2 is not only important for the higher order cognitive aspect of language but also for the motor aspect of speech and language,” said Genevieve Konopka, one of the authors of the paper at UCLA.

Previous research indicates that the changes in FOXP2 occurred around 200,000 years ago with the rise of modern humans. Geschwind also suggests that several of the related genes may have evolved together. Preliminary studies have shown signs that they too emerged relatively recently.

Scientists are now keen to further study FOXP2 and the genes that it affects. Geschwind believes this could eventually lead to breakthroughs in treatment for disorders such as autism and schizophrenia, which affect language skills.

The study was funded by the National Institute of Mental Health, the A.P. Giannini Foundation and the National Alliance for Research on Schizophrenia and Depression.

Tuesday, October 28, 2008

Acting teacher and director Milton Katselas died Friday at age 75, after suffering from heart failure at Cedars-Sinai Medical Center in Los Angeles, California. He began the Beverly Hills Playhouse in 1978 and taught acting classes there to noted actors including George Clooney and Gene Hackman. Katselas is survived by a sister and two brothers.

Katselas directed an off-Broadway production of Edward Albee‘s The Zoo Story, and received a Tony Award nomination for his 1969 direction of Butterflies are Free. Actress Blythe Danner won a Tony Award for her role in Butterflies are Free under Katselas’ direction. He moved to California to direct the film version of that play, and went on to direct films and television movies. Actress Eileen Heckart received an Academy Award for her role in the film version of Butterflies are Free.

Katselas directed the San Francisco and Los Angeles productions of the play P.S. Your Cat Is Dead! by playwright James Kirkwood, Jr. In his author’s notes in the publication of the script, Kirkwood acknowledged Katselas, and wrote that the plays were “directed with incredible energy and enthusiasm by Milton Katselas, to whom I am extremely indebted”.

Katselas directed the television movie Strangers: Story of a Mother and Daughter, and actress Bette Davis received an Emmy Award for her role in the movie. Katselas taught many famous actors including Michelle Pfeiffer, Richard Gere, Robert Duvall, Jack Lemmon, Al Pacino, Goldie Hawn, Christopher Walken, Burt Reynolds, George C. Scott, Elizabeth Taylor, Richard Burton, Alec Baldwin, and Patrick Swayze. Katselas was credited with being able to nurture actors with raw talent so that they could develop strong Hollywood careers. He utilized innovative techniques in his courses – one course called “Terrorist Theatre” had a simple premise: successfully get an acting role within six weeks or leave the course.

He grew up in Pittsburgh, Pennsylvania to parents who had immigrated from Greece, and graduated from Carnegie Mellon. He studied acting with Lee Strasberg in New York at the Actors Studio, and received advice from directors Joshua Logan and Elia Kazan.

Katselas was a prominent Scientologist, and a July 2007 profile on Katselas in The New York Times Magazine observed that some of his students stopped taking courses at the Beverly Hills Playhouse because they felt they had been pressured to join the Church of Scientology. According to the article, Katselas credited Scientology founder L. Ron Hubbard “for much of his success in life”, and one of his students works at Scientology’s Celebrity Centre. The article commented that some in Los Angeles view the Beverly Hills Playhouse as “a recruitment center for Scientology”.

Katselas met L. Ron Hubbard after moving to California, and began studying Scientology in 1965. The New York Times Magazine reported that he had reached the level of “Operating Thetan, Level 5, or O.T. V.” in 2007. According to The New York Times Magazine when Scientologists proceed up the “The Bridge to Total Freedom” they learn the story of Xenu, and that: “75 million years ago the evil alien Xenu solved galactic overpopulation by dumping 13.5 trillion beings in volcanoes on Earth, where they were vaporized, scattering their souls.” A Church of Scientology publication, Source, lists Katselas as reaching O.T. V. in 1989.

Though some actors felt pressured to join the Church of Scientology after taking courses at the Beverly Hills Playhouse, at least one individual felt Katselas was not active enough with the organization. Actress Jenna Elfman left the Beverly Hills Playhouse because she felt Katselas was not committed enough to Scientology. Katselas had previously directed Elfman in half of Visions and Lovers: Variations on a Theme, two one-act plays about relationships that he had written himself. In 1999 Katselas had planned to adapt the script of Visions and Lovers to a film version, and Elfman was set to reprise her role from the play. In an article in Variety about the project, Elfman commented on her experience working with Katselas: “He is brilliant, and knows me so well as a person and an actress that he gets the most out of me.”

Other prominent Scientologist actors who have studied under Katselas include Giovanni Ribisi, Jason Lee, and Leah Remini. According to Rolling Stone, Katselas also recruited actress Kelly Preston to Scientology. Actress Nancy Cartwright (the voice of Bart Simpson), told Scientology publication Celebrity that Katselas motivated her to get more active in Scientology, and she stated she took the organization’s “Purification Rundown” and her life “took off completely”.

Anne Archer was introduced to Scientology while studying at the Beverly Hills Playhouse, as was former Scientologist and now outspoken critic actor Jason Beghe. Beghe told Roger Friedman of FOX News in April 2008 that “He [Katselas] gets kickbacks”, and that he was brought to a Scientology center by fellow Beverly Hills Playhouse classmate Bodhi Elfman, Jenna Elfman’s husband. In a 1998 article for Buzz Magazine, Randye Hoder wrote “In his class, Katselas is careful not to label anything as a tenet of Scientology, but there is no question that the church’s influence seeps into the playhouse.”

Anne Archer’s husband and fellow Scientologist, producer Terry Jastrow, commented to The New York Times Magazine that Katselas changed the way he experiences life on a day-to-day basis: “I go out in the world and look at human behavior now. I see a woman or man interacting with a saleslady, and I see the artistry in it. Life is an endless unspooling of art, of acting, of painting, of architecture. And where did I learn that? From Milton.”

Actor Anthony Head of Buffy the Vampire Slayer spoke highly of Katselas in a 2002 interview with San Francisco Chronicle: “He’s this wonderfully intuitive teacher and his premise is basically: The only real barriers are the ones we put in front of ourselves. If you say, ‘My character wouldn’t do that’ — bollocks! Ultimately it’s you who wouldn’t say that. Who knows what your character might do.” In the acknowledgements of her 2004 autobiography Are You Hungry, Dear?: Life, Laughs, and Lasagna, actress Doris Roberts wrote: “I thank my friend and acting teacher, the incredible Milton Katselas, for his insights, wisdom, and inspiration, which have helped make me the actress that I am.”

Katselas authored two books: Dreams Into Action: Getting What You Want, first published in 1996 by Dove Books, and Acting Class: Take a Seat, which came out earlier this month. Dreams Into Action, a New York Times Bestseller, sought to modify motivational acting exercises to the field of business.

In an interview in the 2007 book Acting Teachers of America, Katselas commented on his experiences as an acting teacher over the years: “I have very special teachers here at the Beverly Hills Playhouse—some have been with me for over twenty-five years. I believe that to make a difference over the long haul, we need to train teachers. I really care about the craft of acting. It’s absolutely necessary to take the time and patience to really develop an actor.”

Wednesday, April 8, 2009

Ernest Krajniak from Chilton, Wisconsin in the United States has been charged with arson after a lit cigarette ignited gasoline soaked clothes, setting his apartment ablaze.

On Friday April 3, Krajniak, 47, cleaned his entire apartment with about five gallons of gasoline, wiping everything down with the soaked clothes. After he was finished, he piled the soaked clothes in the center of his bedroom, lit a cigarette and then threw what was left of the still lit cigarette, into the pile.

Krajniak never called the fire department and never pulled the alarm. Instead he yelled ‘fire’ a few times then walked to the police station where an ambulance took him to a local hospital for the treatment of minor burns. The fire department later arrived to put out the blaze and his apartment was extensively smoke damaged. 11 other apartments were also damaged, leaving the occupants without a place to stay for at least a week.

“I should have never used that,” said Krajniak during a court appearance on Monday. He admitted to knowing that gasoline was highly flammable. He was arrested and his bond has been set a US$2,500. Krajniak’s next court appearance is scheduled for Monday, April 13. According to WISinfo.com, Krajniak has no prior criminal record.

The careless smoking of cigarettes has been blamed for thousands of fires across the U.S. In January 2008, an unnamed elderly woman in Buffalo, New York was receiving oxygen for medical problems in her home and lit a cigarette and began to smoke it. The oxygen coming from her mask then facilitated the ignition of her clothing, setting her on fire.

In the U.S. in 2002, only 4% of all residential fires were reportedly caused by smoking materials. These fires, however, were responsible for 19% of residential fire fatalities and 9% of injuries. The fatality rate due to smoking is nearly four times higher than the overall residential fire rate; injuries are more than twice as likely. Forty percent of all smoking fires start in the bedroom or living room/family room; in 35% of these fires, bedding or upholstered furniture are the items first ignited.

Friday, June 5, 2009

General Motors Corporation (GM), an American automaker which has filed for bankruptcy protection, announced on Friday that the Penske Automotive Group (PAG) was selected to purchase Saturn Corporation. The transaction should be completed in October.

The purchase includes rights to the Saturn brand, its five current models and its dealership network. Two models would be discontinued, the Sky and Astra. GM would continue building the Aura sedan, the SUV’s, Vue and Outlook for at least two more years.

Saturn has 350 dealers across the United States. The dealers employ more than 13,000 jobs and sell only the Saturn autos. Canadian Saturn dealers are not included in the deal.

According to Penske future Saturn vehicles will be fuel economy focused. An expert indicated that this would move Saturn back to its roots of a entry level car company. PAG is in talks with several international automakers to replace GM after 2011. Automotive News reports that Renault Samsung Motors of Korea is the most likely candidate.

Penske wants Jill Lajdziak, Saturn’s general manager, and Tom LaSorda, former Chrysler President to head up the company when it is independent of GM.

Serra Automotive in Grand Blanc Township, Genesee County, Michigan, is in talks to take a partial ownership in a new Saturn lead by Penske.

Monday, July 18, 2005

An 11-year-old girl faces serious assault charges in California after casting a stone at a group of boys who were throwing water balloons at her. In April, Maribel Cuevas was apprehended by Fresno, California police and spent five days in a detention center after throwing the object at the group of boys who bombarded her with water balloons as she walked down the sidewalk. A 9-year-old boy was hit with the stone, and suffered a wound to his head requiring medical assistance.

Since then, Cuevas has spent one month under house arrest pending court. Cuevas’ lawyer, Richard Beshwate, told the BBC that “They [Fresno police] are treating her like a violent parole offender. It’s not a felony, it’s an 11-year-old acting like an 11-year-old.”

Fresno Police Sergeant Anthony Martinez told reporters: “We responded. We determined a felony assault had taken place and the officers took the actions that were necessary.” Cuevas is due back in court next month on felony assault charges.

The girl was placed in juvenile hall during her five-day detention, with only one 30-minute visit from her parents. She was then placed under a 30 day house arrest and required to wear an electronic monitoring bracelet. The house arrest allowed the girl to attend school.

Maribel, who knows very little English, said that the boy initiated the conflict — the boy also admitted as much.